Product Name: WNK2 (179-193)
Product Number: PE-01AZC95
Size: 200 µg      Price:51.00
1 mg      $US102.00
5 mg      224.00
Peptide Name: WNK2 (179-193)

Product Use: Services as a blocking peptide for use with the WNK2-2 rabbit polyclonal antibody (Cat. No.: AB-NK253-2) that is also available from Kinexus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: CDEDDLKAVATSLDGR

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1706.8 Da

Peptide Purity Percent after Synthesis and Purification: 95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: WNK2 pan-specific antibody (Cat. No.: AB-NK253-2)

Scientific Background: Wnk2 (PRKWNK2) is a protein-serine/threonine kinase of the Other group and Wnk family. It plays a critical role in the regulation of electrolyte homeostasis, signalling survival, and proliferation. Activation requires autophosphorylation of S356. Phosphorylation of S352 also promotes increased phosphotransferase activity. It activates sodiu-coupled chloride cotransporters and inhibits potassium-coupled chloride cotransporters. It is also involved in reducing ERK1/2 activation. ERK1/2 expression can also increase through activation of of MEK1 via Rac1-mediate PAK1 activation. WNK2 may be a tumour suppressor protein (TSP). Wnk2 is also called serologically defined colon cancer antigen 43. Loss of Wnk2 expression was found in adult gliomas and triggers Rac1-mediated tumour cell invasiveness. Loss of expression of Wnk2 is also found in meningioma and facilitates increased cell cycle progression and proliferation.