Product Name: QSK (1249-1263)
Product Number: PE-01AYU85
Size: | 200 µg | | Price: | 38.00 |
| 1 mg | | $US | 77.00 |
Peptide Name: QSK (1249-1263)
Product Use: Services as a blocking peptide for use with the SIK3-3 rabbit polyclonal antibody (Cat. No.: AB-NK250-3) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CYKHPEVSFSMEQAGV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1812 Da
Peptide Purity Percent after Synthesis and Purification: >80
Scientific Background: SIK3 (QSK) is a protein-serine/threonine kinase of the CAMK group and CAMKL family. It is a member of the salt-inducible kinase family. SIK3 is activated by phosphorylation on T163 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. It is a AMPK-family kinase that is ubiquitously expressed in the cytoplasm. In ovarian cancer, overexpression of SIK3 promotes G1/S cell cycle progression and cell proliferation and may therefore function as an oncoprotein.