Product Name: MEK7 (104-118)
Product Number: PE-01AWJ95
Size: 200 µg      Price:45.00
1 mg      $US90.00
Peptide Name: MEK7 (104-118)

Product Use: Services as a blocking peptide for use with the MKK7-1 rabbit polyclonal antibody (Cat. No.: AB-NK106-3) that is also available from Kinexus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: CGYLTIGGQRYQAEIN

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1785 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: MEK7 pan-specific antibody (Cat. No.: AB-NK106-3)

Scientific Background: MKK7 (MAP2K7, MEK7) is a dual-specificity protein kinase that functions in the MAP kinase (MAPK) and the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signalling pathways. It acts as an essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signalling pathway. It is activated by phosphorylation at S271 and T275 in the kinase activation loop by specific MAP kinase kinase kinases including MAP3K1 (MEKK1), MAP3K3 (MEKK3), MAP3K11 (MLK3) and MAP3K12 (DLK). With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. MEK7 has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signalling pathway is also involved in mitochondrial death signalling pathway, including the release cytochrome c, leading to apoptosis.