Product Name: MEK3 (311-325)
Product Number: PE-01AWC85
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Peptide Name: MEK3 (311-325)
Product Use: Services as a blocking peptide for use with the MKK3-2 rabbit polyclonal antibody (Cat. No.: AB-NK101-5) that is also available from Kinexus. The peptide sequence is located in the kinase catalytic domain last alpha-chain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CAERMSYLELMEHPFF
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2002.3 Da
Peptide Appearance: White powder
Peptide Form: Solid
Product Use: Services as a blocking peptide for use with the MKK3-2 rabbit polyclonal antibody (Cat. No.: AB-NK101-5) that is also available from Kinexus. The peptide sequence is located in the kinase catalytic domain last alpha-chain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CAERMSYLELMEHPFF
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2002.3 Da
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Powder and solution tend to dimerize; stable as dimer
Related Product 1: MEK3 pan-specific antibody (Cat. No.: AB-NK101-5)
Storage Stability: Powder and solution tend to dimerize; stable as dimer
Related Product 1: MEK3 pan-specific antibody (Cat. No.: AB-NK101-5)
Scientific Background: MKK3 (MAP2K3, MEK3) is a Dual specificity protein kinase of the STE group and STE7 family. MKK3 is activated by cytokines and environmental stress in vivo. Phosphorylation of S218 and T222 increases its phosphotransferase activity. S218A and T222A substitutions are involved in inactivation. S218E and T222E mutations are associated in constitutive activation. It catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the activation T loops of the p38 MAP kinase isoforms. Defects in the MKK3 gene may be involved colon cancer.
© Kinexus Bioinformatics Corporation 2017