Product Name: Tyk2 (1151-1166)
Product Number: PE-01AVL80
Size: | 200 µg | | Price: | 38.00 |
| 1 mg | | $US | 77.00 |
| 5 mg | | | 166.00 |
Peptide Name: Tyk2 (1151-1166)
Product Use: Services as a blocking peptide for use with the TYK2-3 rabbit polyclonal antibody (Cat. No.: AB-NK181-5) that is also available from Kinexus. The peptide sequence is located in the kinase catalytic domain last alpha-chain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CWETEASFRPTFENLI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1942.2 Da
Peptide Purity Percent after Synthesis and Purification: >80
Scientific Background: Tyk2 is a protein-tyrosine kinase of the TK group and JakA family. Phosphorylation of Y1054 and Y1055 increases phosphotransferase activity. Tyk2 mediates intracellular signal transduction from Type I interferon-alpha/beta receptor (IFN) signalling and phosphorylates the interferon-alpha/beta receptor alpha chain. Missense mutations in this gene have been found in colon and ovarian tumours.