Product Name: Tyk2 (886-900)
Product Number: PE-01AVK99
Size: | 200 µg | | Price: | 12.00 |
| 1 mg | | $US | 23.00 |
Peptide Name: Tyk2 (886-900)
Product Use: Services as a blocking peptide for use with the TYK2-2 rabbit polyclonal antibody (Cat. No.: AB-NK181-4) that is also available from Kinexus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CASDPTVFHKRYLKKI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1905.3 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Scientific Background: Tyk2 is a protein-tyrosine kinase of the TK group and JakA family. Phosphorylation of Y1054 and Y1055 increases phosphotransferase activity. Tyk2 mediates intracellular signal transduction from Type I interferon-alpha/beta receptor (IFN) signalling and phosphorylates the interferon-alpha/beta receptor alpha chain. Missense mutations in this gene have been found in colon and ovarian tumours.