Product Name: TRRAP (3513-3527)
Product Number: PE-01ATL99
| Size: | 200 µg | Price: | 51.00 | |
| 1 mg | $US | 102.00 | ||
| 5 mg | 224.00 |
Peptide Name: TRRAP (3513-3527)
Product Use: Services as a blocking peptide for use with the TRRAP rabbit polyclonal antibody (Cat. No.: AB-NK232) that is also available from Kinexus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CARRLYIRGHNGKIYP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1916.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Product Use: Services as a blocking peptide for use with the TRRAP rabbit polyclonal antibody (Cat. No.: AB-NK232) that is also available from Kinexus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CARRLYIRGHNGKIYP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1916.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TRRAP pan-specific antibody (Cat. No.: AB-NK232)
Storage Conditions: -20°C
Related Product 1: TRRAP pan-specific antibody (Cat. No.: AB-NK232)
Scientific Background: TRRAP is a protein-serine/threonine kinase and transcription, coactivator/corepressor of the Atypical group and PIKK family. It is a multidomain kinase that belongs to the phosphoinositide-3-kinase-related kinase (PIKK) family. The TRRAP protein functions as an adaptor protein in various multiprotein chromatin complexes that collectively display histone acetyltransferase activity (HAT) and function in the epigenetic regulation of transcriptional activity. in addition, TRRAP is a component of the NuA4 histone acetyltransferase complex, which mediates the acetylation of histones H4 and H2A. TRRAP may be an oncoprotein (OP). TRRAP mediates the transcriptional activation induced by the adenovirus E1A. In addition, TRRAP plays a critical role in the regulation of Myc activation and is involved in Myc-mediated cell transformation. Several mutations (e.g. S722P in cutaneous malignant melanoma cells) in the TRRAP gene have been observed in human cancers. Knockdown of the mutant S722P TRRAP protein with siRNA in melanoma cancer cells results in increased apoptosis, indicating that the mutant TRRAP protein is essential for melanoma cell survival and tumour progression. In animal models, Cre-lox mediated knockdown of TRRAP expression lead to reduced cell proliferation due to the necessity of TRRAP for the regulation of the mitotic checkpoint and normal progression through the cell cycle.
© Kinexus Bioinformatics Corporation 2017