Product Name: ASK2 (409-424)
Product Number: PE-01ASQ99
Size: 200 µg      Price:51.00
1 mg      $US102.00
5 mg      224.00
Peptide Name: ASK2 (409-424)

Product Use: Services as a blocking peptide for use with the MEKK6-1 rabbit polyclonal antibody (Cat. No.: AB-NK225-4) that is also available from Kinexus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: FEDSKELRLIGMKLGC

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1838.2 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: ASK2 pan-specific antibody (Cat. No.: AB-NK225-4)

Scientific Background: MEKK6 (ASK2, MAP3K6) is a protein-serine/threonine kinase of the STE group and STE11 family. It apparently regulates the JNK, but not ERK or p38 kinase pathways. It is activated by phosphorylation on T806 in the kinase activation loop. It is catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6, and MAP3K6 activating MAP3K5 by direct phosphorylation. It may be a tumour suppressor protein (TSP). However, its extremely low rate of mutation in human tumours indicates that it may also act as a tumour requiring protein (TRP). MEKK6 can form a heterocomplex with MAP3K5 (ASK1) to act as a proapoptotic signal and tumour suppressor protein. The P946L, F849Sfs*142, P958T, D200Y and V207G variants have been linked to familial gastric cancer, and they were predicted to be variants that lead to either a decrease in function or dominant negative phenotype. Studies with mouse models also support the role of ASK2 as a tumour suppressor.