Product Name: CLEC16A (390-404)
Product Number: PE-01AMC90
Size: 200 µg      Price:42.00
1 mg      $US84.00
5 mg      198.00
Peptide Name: CLEC16A (390-404)

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: RPNYKNVGEEEDEEK

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1835.9 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: CLEC16A is a C-type lectin domain family member that acts as a modulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. It may protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. It plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. It is almost exclusively expressed in immune cells. Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes CLEC16A.
References

[1] Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature. 2007 Aug 2;448(7153):591-4. Epub 2007 Jul 15. PMID:17632545

[2] Soleimanpour, S. A., Gupta, A., Bakay, M., Ferrari, A. M., Groff, D. N., Fadista, J., & Stoffers, D. A. (2014). The diabetes susceptibility gene Clec16a regulates mitophagy. Cell, 157(7), 1577-1590; PMID:9271417