Product Name: BDC2.5 Mimotope 1040-63, mouse
Product Number: PE-01AES95
Size: 1 mg      Price:64.00
5 mg      $US140.00
20 mg      256.00
Peptide Name: BDC2.5 Mimotope 1040-63, mouse

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Mus musculus

Peptide Sequence: RTRPLWVRME

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1342.6 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: T1D is an autoimmune disease in which T cells mediate damage to pancreatic islet ß cells. T1D is caused by autoreactive T cell destruction of insulin-producing cells. BDC2.5 mimotope was utilized to support the study on antigen presentation of antigenic peptides to islet autoantigen-specific T cells.
References

[1] Michael Mingueneau, Wenyu Jiang, Markus Feuerer, Diane Mathis, Christophe Benoist. Thymic negative selection is functional in NOD mice. J Exp Med. 2012 March 12; 209(3): 623–637. PMCID: PMC3302233; doi: 10.1084/jem.20112593

[2] Martin-Orozco, N., Z. Chen, L. Poirot, E. Hyatt, A. Chen, O. Kanagawa, A. Sharpe, D. Mathis, and C. Benoist. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J. Immunol. 171: 6954–6960. PMID: 14662903

[3] Hu CY, Rodriguez-Pinto D, Du W, Ahuja A, Henegariu O, Wong FS, Shlomchik MJ, Wen L. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest. 2007 Dec;117(12):3857-67. PMID: 18060033