Product Name: EIF2S1 (46-57)
Product Number: PE-01ACR95
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 83.00 |
Peptide Name: EIF2S1 (46-57)
Product Use: For assaying the phosphotransferase activities of MAP kinase-interacting serine-threonine kinase 1 (MNK1, UniProt ID Q9BUB5), Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2, UniProt ID P19525), Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, UniProt ID Q9NZJ5), and Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4 (GCN2), UniProt ID Q9P2K8).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on EIF2S1 phosphosite
Peptide Sequence: CILLSELSRRRIR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Product Use: For assaying the phosphotransferase activities of MAP kinase-interacting serine-threonine kinase 1 (MNK1, UniProt ID Q9BUB5), Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2, UniProt ID P19525), Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, UniProt ID Q9NZJ5), and Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4 (GCN2), UniProt ID Q9P2K8).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on EIF2S1 phosphosite
Peptide Sequence: CILLSELSRRRIR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1614.99 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: MNK1; EIF2AK2; EIF2AK3; EIF2AK4 (GCN2)
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: MNK1; EIF2AK2; EIF2AK3; EIF2AK4 (GCN2)
Scientific Background: EIF2S1 mediates early steps in protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex subsequently binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. For eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
© Kinexus Bioinformatics Corporation 2017