Product Name: GluR2 (844-858) del 849-853
Product Number: PE-01ABL90
| Size: | 200 µg | Price: | 28.00 | |
| 1 mg | $US | 56.00 | ||
| 5 mg | 132.00 |
Peptide Name: GluR2 (844-858) del 849-853
Product Use: Peptide disrupts AP2 but not NSF binding and prevents AMPA receptor endocytosis and LTD without affecting basal synaptic transmission. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KRMKLNINPS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1199.5 Da
Peptide Purity Percent after Synthesis and Purification: >90
Product Use: Peptide disrupts AP2 but not NSF binding and prevents AMPA receptor endocytosis and LTD without affecting basal synaptic transmission. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KRMKLNINPS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1199.5 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: GLuR2 is a receptor for the excitatory neurotransmitter L-glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. Binding of L-glutamate induces a conformation change, leading to the opening of the cation channel, and to generate an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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