Product Name: HIV1 Tat (47-57)
Product Number: PE-01AAK90
| Size: | 1 mg | Price: | 62.00 | |
| 5 mg | $US | 145.00 | ||
| 20 mg | 229.00 |
Peptide Name: HIV1 Tat (47-57)
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Human immunodeficiency virus 1
Peptide Sequence: YGRKKRRQRRR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1558.8 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: Yellow wax
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Human immunodeficiency virus 1
Peptide Sequence: YGRKKRRQRRR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1558.8 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: Yellow wax
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: This arginine-rich Tat peptide penetrates plasma membrane directly, but not through endocytosis.
References
[1] Wang HY, Fu T, Wang G, Zeng G, Perry-Lalley DM, Yang JC, Restifo NP, Hwu P, Wang RF. Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells. J Clin Invest. 2002 Jun;109(11):1463-70. PMID: 12045260.
[2] Ziegler A, Nervi P, Dürrenberger M, Seelig J. The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence. Biochemistry. 2005 Jan 11;44(1):138-48. PMID: 15628854.
[3] Wender PA, Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L, Rothbard JB. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13003-8. PMID: 11087855.
[1] Wang HY, Fu T, Wang G, Zeng G, Perry-Lalley DM, Yang JC, Restifo NP, Hwu P, Wang RF. Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells. J Clin Invest. 2002 Jun;109(11):1463-70. PMID: 12045260.
[2] Ziegler A, Nervi P, Dürrenberger M, Seelig J. The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence. Biochemistry. 2005 Jan 11;44(1):138-48. PMID: 15628854.
[3] Wender PA, Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L, Rothbard JB. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13003-8. PMID: 11087855.
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