Target Full Name: U1 small nuclear ribonucleoprotein 70 kDa

Target Alias: RNPU1Z; RPU1; RU17; small nuclear ribonucleoprotein 70kDa (U1); Snp1; SNRNP70; SNRP70; U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; U170K; U1AP; U1AP1; U1RNP

Product Type Specific: snRNP 70 phosphosite-specific antibody

Antibody Code: PN537

Antibody Target Type: Phosphosite-specific

Antibody Phosphosite: Y126

Protein UniProt: P08621

Protein SigNET: P08621

Antibody Type: Polyclonal

Antibody Host Species: Rabbit

Antibody Immunogen Source: Human snRNP 70 sequence peptide Cat. No.: PE-04AFF99

Antibody Immunogen Sequence: FEV(pY)GPI(bA)C

Antibody Immunogen Description: Corresponds to amino acid residues F123 to I129; In the RRM_1 domain. This is the major in vivo phosphorylation site in snRNP70.

Production Method: The immunizing peptide was produced by solid phase synthesis on a multipep peptide synthesizer and purified by reverse-phase hplc chromatography. Purity was assessed by analytical hplc and the amino acid sequence confirmed by mass spectrometry analysis. This peptide was coupled to KLH prior to immunization into rabbits. New Zealand White rabbits were subcutaneously injected with KLH-coupled immunizing peptide every 4 weeks for 4 months. The sera from these animals was applied onto an agarose column to which the immunogen peptide was thio-linked. Antibody was eluted from the column with 0.1 M glycine, pH 2.5. Subsequently, the antibody solution was neutralized to pH 7.0 with saturated Tris.This antibody was also subject to negative purification over phosphotyrosine-agarose.

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.