Target Full Name: Annexin A2

Target Alias: Annexin II; Annexin-2; ANX2; ANX2L4; anxa 2; ANXA2; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; LIP2; Lipocortin II; LPC2; LPC2D; p36; PAP-IV; Placental anticoagulant protein IV; Protein I

Product Type Specific: Annexin phosphosite-specific antibody

Antibody Code: PN504

Antibody Target Type: Phosphosite-specific

Antibody Phosphosite: Y238

Protein UniProt: P07355

Protein SigNET: P07355

Antibody Type: Polyclonal

Antibody Host Species: Rabbit

Antibody Immunogen Source: Human ANXA2 sequence peptide Cat. No.: PE-04ACI99

Antibody Immunogen Sequence: YSP(pY)DML(bA)C

Antibody Immunogen Description: Corresponds to amino acid residues Y235 to L241; In the third Annexin domain. The second major in vivo phosphoryation site in Annexin A2.

Production Method: The immunizing peptide was produced by solid phase synthesis on a multipep peptide synthesizer and purified by reverse-phase hplc chromatography. Purity was assessed by analytical hplc and the amino acid sequence confirmed by mass spectrometry analysis. This peptide was coupled to KLH prior to immunization into rabbits. New Zealand White rabbits were subcutaneously injected with KLH-coupled immunizing peptide every 4 weeks for 4 months. The sera from these animals was applied onto an agarose column to which the immunogen peptide was thio-linked. Antibody was eluted from the column with 0.1 M glycine, pH 2.5. Subsequently, the antibody solution was neutralized to pH 7.0 with saturated Tris.This antibody was also subject to negative purification over phosphotyrosine-agarose.

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.