Product Name: TrpC5
Product Number: AB-NN350-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Short transient receptor potential channel 5
Target Alias: Htrp5; TRP5
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN350-1
Antibody Target Type: Pan-specific
Protein UniProt: Q9UL62
Protein SigNET: Q9UL62
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2b
Antibody Immunogen Source: Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)
Target Alias: Htrp5; TRP5
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN350-1
Antibody Target Type: Pan-specific
Protein UniProt: Q9UL62
Protein SigNET: Q9UL62
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2b
Antibody Immunogen Source: Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5)
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~110 kDa protein by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-344 was sufficient for detection of TrpC5 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Related Product 1: TrpC7 pan-specific antibody (Cat. No.: AB-NN351-1)
Related Product 2: TrpM7 pan-specific antibody (Cat. No.: AB-NK305-1)
Related Product 3: TrpV3 pan-specific antibody (Cat. No.: AB-NN353-1)
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-344 was sufficient for detection of TrpC5 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Related Product 1: TrpC7 pan-specific antibody (Cat. No.: AB-NN351-1)
Related Product 2: TrpM7 pan-specific antibody (Cat. No.: AB-NK305-1)
Related Product 3: TrpV3 pan-specific antibody (Cat. No.: AB-NN353-1)
Scientific Background: Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is a subtype of the TRPC family of mammalian transient receptor potential ion channels. Homo-multimeric TRPC5 and hetero-multimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin (1). This activation probably plays a role in rheumatoid arthritis. It has also been recently found to be involved in the action on anaesthetics such as chloroform, halothane and propofol (2).
References
[1] Xu S.Z. et al. (2008) Nature 451(7174): 69-72.
[2] Bahnasi Y.M. et al. (2008) Br J. Pharamcol. 153(7): 1505-1512.
[1] Xu S.Z. et al. (2008) Nature 451(7174): 69-72.
[2] Bahnasi Y.M. et al. (2008) Br J. Pharamcol. 153(7): 1505-1512.
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