Product Name: GluN2A/NR2A
Product Number: AB-NN297-2
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Glutamate receptor ionotropic, NMDA 2A
Target Alias: NMDA 2A; NMDAR2A; NMDAR 2A; NMDA Receptor 2A; Glutamate Receptor; GRIN2A; Glutamate [NMDA] Receptor subunit epsilon-1; Glutamate receptor ionotropic N methyl D aspartate 2A; HNR2A; N methyl D aspartate receptor channel; subunit epsilon 1; N Methyl D Aspartate Receptor Subtype 2A; N methyl D aspartate receptor subunit 2A; NMDA receptor subtype 2A; NMDA Receptor Type 2A; OTTHUMP00000160135; OTTHUMP00000174531
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN297-2
Antibody Target Type: Pan-specific
Protein UniProt: Q12879
Protein SigNET: Q12879
Antibody Type: Monoclonal
Target Alias: NMDA 2A; NMDAR2A; NMDAR 2A; NMDA Receptor 2A; Glutamate Receptor; GRIN2A; Glutamate [NMDA] Receptor subunit epsilon-1; Glutamate receptor ionotropic N methyl D aspartate 2A; HNR2A; N methyl D aspartate receptor channel; subunit epsilon 1; N Methyl D Aspartate Receptor Subtype 2A; N methyl D aspartate receptor subunit 2A; NMDA receptor subtype 2A; NMDA Receptor Type 2A; OTTHUMP00000160135; OTTHUMP00000174531
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN297-2
Antibody Target Type: Pan-specific
Protein UniProt: Q12879
Protein SigNET: Q12879
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2b
Antibody Immunogen Source: Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Antibody Ig Isotype Clone: IgG2b
Antibody Immunogen Source: Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~170 kDa protein by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-434 was sufficient for detection of GluN2A/NR2A in 20 µg of COS cells transiently transfected with GFP-tagged NR2A lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Antibody Cross Reactivity: Does not react with NR2B.
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~170 kDa protein by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-434 was sufficient for detection of GluN2A/NR2A in 20 µg of COS cells transiently transfected with GFP-tagged NR2A lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Antibody Cross Reactivity: Does not react with NR2B.
Related Product 1: GluN2A/NR2A pan-specific antibody (Cat. No.: AB-NN297-1)
Related Product 2: GluA1/GluR1 Glutamate Receptor pan-specific antibody (Cat. No.: AB-NN263-1)
Related Product 3: GluN1/NR1 pan-specific antibody (Cat. No.: AB-NN264-1)
Related Product 2: GluA1/GluR1 Glutamate Receptor pan-specific antibody (Cat. No.: AB-NN263-1)
Related Product 3: GluN1/NR1 pan-specific antibody (Cat. No.: AB-NN264-1)
Scientific Background: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D).
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