Product Name: Kir2.2
Product Number: AB-NN278-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: ATP-sensitive inward rectifier potassium channel 12

Target Alias: IRK2; KCNJ12; kcnj12x; KCNJN1; Kir2.2v; potassium inwardly rectifying channel subfamily J member 12

Product Type Specific: Potassium channel pan-specific antibody

Antibody Code: NN278-1

Antibody Target Type: Pan-specific

Protein UniProt: Q14500

Protein SigNET: Q14500

Antibody Type: Monoclonal

Antibody Host Species: Mouse

Antibody Ig Isotype Clone: IgG1

Antibody Immunogen Source: Fusion protein amino acids 362-427 of rat Kir2.2

Production Method: Protein G purified

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence

Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Antibody Potency: Medium potency. Detects a ~45 kDa protein in cell and tissue lysates by Western blotting.

Antibody Species Reactivity: Human | Mouse | Rat

Antibody Positive Control: 1 µg/ml of SMC-311 was sufficient for detection of Kir2.2 in 30 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Antibody Specificity: Very high

Antibody Cross Reactivity: No cross-reactivity against Kir2.2 or Kir2.3.

Related Product 1: Kir2.3 pan-specific antibody (Cat. No.: AB-NN279-1)

Scientific Background: The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A defect in this gene is associated with Andersen-Tawil syndrome (1).