Product Name: KCNQ1
Product Number: AB-NN274-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Potassium voltage-gated channel subfamily KQT member 1
Target Alias: ATFB1; ATFB3; FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Jervell and Lange-Nielsen syndrome 1; JLNS1; KCNA8; KCNA9; KCNQ1; KCNQ1_HUMAN; kidney and cardiac voltage dependend K+ channel; KQT-like 1; Kv1.9; Kv7.1; KVLQT1; long (electrocardiographic) QT syndrome; Ward-Romano syndrome 1; LQT; LQT1; Potassium voltage-gated channel KQT-like subfamily member 1; RWS; slow delayed rectifier channel subunit; SQT2; Voltage-gated potassium channel subunit Kv7.1; WRS
Product Type Specific: Potassium channel pan-specific antibody
Antibody Code: NN274-1
Antibody Target Type: Pan-specific
Protein UniProt: P51787
Target Alias: ATFB1; ATFB3; FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Jervell and Lange-Nielsen syndrome 1; JLNS1; KCNA8; KCNA9; KCNQ1; KCNQ1_HUMAN; kidney and cardiac voltage dependend K+ channel; KQT-like 1; Kv1.9; Kv7.1; KVLQT1; long (electrocardiographic) QT syndrome; Ward-Romano syndrome 1; LQT; LQT1; Potassium voltage-gated channel KQT-like subfamily member 1; RWS; slow delayed rectifier channel subunit; SQT2; Voltage-gated potassium channel subunit Kv7.1; WRS
Product Type Specific: Potassium channel pan-specific antibody
Antibody Code: NN274-1
Antibody Target Type: Pan-specific
Protein UniProt: P51787
Protein SigNET: P51787
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 2-101 of human KCNQ1
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 2-101 of human KCNQ1
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Medium potency. Detects a ~75 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat | Hamster
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Medium potency. Detects a ~75 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat | Hamster
Antibody Positive Control: 1 µg/ml of SMC-307 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: High
Related Product 1: KCNQ2 pan-specific antibody (Cat. No.: AB-NN275-1)
Related Product 2: KCNQ4 pan-specific antibody (Cat. No.: AB-NN276-1)
Antibody Specificity: High
Related Product 1: KCNQ2 pan-specific antibody (Cat. No.: AB-NN275-1)
Related Product 2: KCNQ4 pan-specific antibody (Cat. No.: AB-NN276-1)
Scientific Background: Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (1) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (2, 3).
References
[1] Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208.
[2] Kurokawa J. et al. (2009) Channels (Austin). 3(1): 16-24.
[3] Silva J., and Rudy Y. (2005) Circulation. 112(10): 1384-1391.
[1] Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208.
[2] Kurokawa J. et al. (2009) Channels (Austin). 3(1): 16-24.
[3] Silva J., and Rudy Y. (2005) Circulation. 112(10): 1384-1391.
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