Product Name: Cav1.3
Product Number: AB-NN226-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Voltage-dependent L-type calcium channel subunit alpha-1D
Target Alias: alpha-1 polypeptide; CAC1D_HUMAN; CACH3; CACN4; CACNA 1D; Cacna1d; CACNL1A2; Calcium channel; Calcium channel L type alpha 1 polypeptide isoform 2; Calcium channel neuroendocrine/brain type alpha 1 subunit; Calcium channel voltage dependent L type alpha 1D subunit; CCHL1A2; isoform 2; L type; Voltage dependent L type calcium channel subunit alpha 1D; Voltage gated calcium channel alpha 1 subunit; Voltage gated calcium channel alpha subunit Cav1.3; Voltage gated calcium channel subunit alpha Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3
Product Type Specific: Caclium channel pan-specific antibody
Antibody Code: NN226-1
Antibody Target Type: Pan-specific
Protein UniProt: Q01668
Target Alias: alpha-1 polypeptide; CAC1D_HUMAN; CACH3; CACN4; CACNA 1D; Cacna1d; CACNL1A2; Calcium channel; Calcium channel L type alpha 1 polypeptide isoform 2; Calcium channel neuroendocrine/brain type alpha 1 subunit; Calcium channel voltage dependent L type alpha 1D subunit; CCHL1A2; isoform 2; L type; Voltage dependent L type calcium channel subunit alpha 1D; Voltage gated calcium channel alpha 1 subunit; Voltage gated calcium channel alpha subunit Cav1.3; Voltage gated calcium channel subunit alpha Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3
Product Type Specific: Caclium channel pan-specific antibody
Antibody Code: NN226-1
Antibody Target Type: Pan-specific
Protein UniProt: Q01668
Protein SigNET: Q01668
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2a Kappa
Antibody Immunogen Source: Fusion protein amino acids 859-875 of rat Cav1.3
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2a Kappa
Antibody Immunogen Source: Fusion protein amino acids 859-875 of rat Cav1.3
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~250 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~250 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-301 was sufficient for detection of Cav1.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: High
Antibody Cross Reactivity: No cross-reactivity against Cav1.2.
Related Product 1: Cav beta 1 pan-specific antibody (Cat. No.: AB-NN222-1)
Related Product 2: Cav beta 2 pan-specific antibody (Cat. No.: AB-NN228-1)
Related Product 3: Cav beta 4 pan-specific antibody (Cat. No.: AB-NN223-1)
Related Product 4: Cav1.2 pan-specific antibody (Cat. No.: AB-NN225-1)
Related Product 5: Cav3.1 pan-specific antibody (Cat. No.: AB-NN227-1)
Antibody Specificity: High
Antibody Cross Reactivity: No cross-reactivity against Cav1.2.
Related Product 1: Cav beta 1 pan-specific antibody (Cat. No.: AB-NN222-1)
Related Product 2: Cav beta 2 pan-specific antibody (Cat. No.: AB-NN228-1)
Related Product 3: Cav beta 4 pan-specific antibody (Cat. No.: AB-NN223-1)
Related Product 4: Cav1.2 pan-specific antibody (Cat. No.: AB-NN225-1)
Related Product 5: Cav3.1 pan-specific antibody (Cat. No.: AB-NN227-1)
Scientific Background: CaV1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. CaV1.3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that CaV1.3 is also found in the atria, and may figure prominently in atrial arrhythmias (1). CaV1.3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells (2).
References
[1] Zhang Z. et al. (2005) Circulation 112: 1936-1944.
[2] Johnson S.L. and Marcotti W. (2008) The Journal of Physiology. 586: 1029-1042.
[1] Zhang Z. et al. (2005) Circulation 112: 1936-1944.
[2] Johnson S.L. and Marcotti W. (2008) The Journal of Physiology. 586: 1029-1042.
© Kinexus Bioinformatics Corporation 2017