Product Name: Cav1.2
Product Number: AB-NN225-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Voltage dependent L type calcium channel subunit alpha 1D
Target Alias: CACH3; CACN4; CACNA 1D; CACNL1A2; alpha-1 subunit voltage-dependent calcium channel; calcium channel voltage-dependent L type alpha 1C subunit1; voltage-gated calcium channel alpha subunit Cav1.2; calcium channel L type; alpha 1 polypeptide isoform 1 cardic muscle; calcium channel cardic dihydropyridine-sensitive alpha-1 subunit; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10; DHPR alpha-1 subunit; Voltage-gated calcium channel subunit alpha Cav1.2; Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN225-1
Antibody Target Type: Pan-specific
Protein UniProt: P15381
Target Alias: CACH3; CACN4; CACNA 1D; CACNL1A2; alpha-1 subunit voltage-dependent calcium channel; calcium channel voltage-dependent L type alpha 1C subunit1; voltage-gated calcium channel alpha subunit Cav1.2; calcium channel L type; alpha 1 polypeptide isoform 1 cardic muscle; calcium channel cardic dihydropyridine-sensitive alpha-1 subunit; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10; DHPR alpha-1 subunit; Voltage-gated calcium channel subunit alpha Cav1.2; Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN225-1
Antibody Target Type: Pan-specific
Protein UniProt: P15381
Protein SigNET: P15381
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: High potency. Detects a ~240 kDa protein (varies with cell background due to glycosylation).
Antibody Species Reactivity: Human | Mouse | Rat | Hamster
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: High potency. Detects a ~240 kDa protein (varies with cell background due to glycosylation).
Antibody Species Reactivity: Human | Mouse | Rat | Hamster
Antibody Positive Control: 1 µg/ml of SMC-300 was sufficient for detection of Cav1.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Medium-High
Related Product 1: Cav beta 1 pan-specific antibody (Cat. No.: AB-NN222-1)
Related Product 2: Cav beta 2 pan-specific antibody (Cat. No.: AB-NN228-1)
Related Product 3: Cav beta 4 pan-specific antibody (Cat. No.: AB-NN223-1)
Related Product 4: Cav1.3 pan-specific antibody (Cat. No.: AB-NN226-1)
Related Product 5: Cav3.1 pan-specific antibody (Cat. No.: AB-NN227-1)
Antibody Specificity: Medium-High
Related Product 1: Cav beta 1 pan-specific antibody (Cat. No.: AB-NN222-1)
Related Product 2: Cav beta 2 pan-specific antibody (Cat. No.: AB-NN228-1)
Related Product 3: Cav beta 4 pan-specific antibody (Cat. No.: AB-NN223-1)
Related Product 4: Cav1.3 pan-specific antibody (Cat. No.: AB-NN226-1)
Related Product 5: Cav3.1 pan-specific antibody (Cat. No.: AB-NN227-1)
Scientific Background: Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (1). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (2, 3) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (3).
References
[1] Splawski I. et al. (2004) Cell. 119 (1): 19-31.
[2] Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a.
[3] Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.
[1] Splawski I. et al. (2004) Cell. 119 (1): 19-31.
[2] Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a.
[3] Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.
© Kinexus Bioinformatics Corporation 2017