Product Name: TARP Gamma2/4/8 (Stargazin)
Product Number: AB-NN224-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Voltage-dependent calcium channel gamma-2 subunit
Target Alias: CACNG2; Calcium channel voltage dependent gamma subunit 2; CaV gamma 2; Ipr328; MGC123981; MGC138502; MGC138504; Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; Stg; Stargazer; TARP; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2; AW060990; B230105C07Rik; B930041E13Rik; Wag; Waggler
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN224-1
Antibody Target Type: Pan-specific
Protein UniProt: Q9Y698
Protein SigNET: Q9Y698
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Target Alias: CACNG2; Calcium channel voltage dependent gamma subunit 2; CaV gamma 2; Ipr328; MGC123981; MGC138502; MGC138504; Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; Stg; Stargazer; TARP; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2; AW060990; B230105C07Rik; B930041E13Rik; Wag; Waggler
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN224-1
Antibody Target Type: Pan-specific
Protein UniProt: Q9Y698
Protein SigNET: Q9Y698
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2A
Antibody Immunogen Source: Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | ICC/Immunofluorescence
Antibody Immunogen Source: Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~35-55 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-422 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Cross Reactivity: Does not cross-react with TARPGamma3.
Related Product 1: TARP Gamma2/Stargazin pan-specific antibody (Cat. No.: AB-NN224-2)
Antibody Potency: Detects a ~35-55 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-422 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Cross Reactivity: Does not cross-react with TARPGamma3.
Related Product 1: TARP Gamma2/Stargazin pan-specific antibody (Cat. No.: AB-NN224-2)
Scientific Background: Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.
References
[1] Gill M.B. et al. (2011) J Neurosci. 31(18): 6928-6938.
[2] Yu L. (2011) Neuroscience. 178: 13-20.
[3] Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690.
[4] Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977.
[5] Letts V.A. et al. (1998) Nat Genet. 19: 340-34
[1] Gill M.B. et al. (2011) J Neurosci. 31(18): 6928-6938.
[2] Yu L. (2011) Neuroscience. 178: 13-20.
[3] Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690.
[4] Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977.
[5] Letts V.A. et al. (1998) Nat Genet. 19: 340-34
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