Product Name: Amyloid Oligomers (A11)
Product Number: AB-NN198-1
| Size: | 25 µl | Price: | 89.00 | |
| $US |
Target Full Name: Amyloid beta A4 protein
Target Alias: Amyloid Oligomer αβ; A11; Amyloid Oligomer AlphaBeta; APP
Product Type Specific: Amyloid protein pan-specific antibody
Antibody Code: NN198-1
Antibody Target Type: Pan-specific
Protein UniProt: P05067
Protein SigNET: P05067
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Ig Isotype Clone: N/A
Antibody Immunogen Source: Synthetic molecular mimic of soluble oligomers
Production Method: Protein A purified
Target Alias: Amyloid Oligomer αβ; A11; Amyloid Oligomer AlphaBeta; APP
Product Type Specific: Amyloid protein pan-specific antibody
Antibody Code: NN198-1
Antibody Target Type: Pan-specific
Protein UniProt: P05067
Protein SigNET: P05067
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Ig Isotype Clone: N/A
Antibody Immunogen Source: Synthetic molecular mimic of soluble oligomers
Production Method: Protein A purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation | ELISA
Antibody Dilution Recommended: WB (1:1000), IP (1:1000); optimal dilutions for assays should be determined by the user.
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation | ELISA
Antibody Dilution Recommended: WB (1:1000), IP (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Antibody Species Reactivity: Human | Mouse | Rat | Eukaryotes
Antibody Positive Control: A 1:1000 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 µg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Related Product 1: Amyloid Fibrils (OC) pan-specific antibody (Cat. No.: AB-NN194-1)
Antibody Species Reactivity: Human | Mouse | Rat | Eukaryotes
Antibody Positive Control: A 1:1000 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 µg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Related Product 1: Amyloid Fibrils (OC) pan-specific antibody (Cat. No.: AB-NN194-1)
Scientific Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson’s disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease (2, 3).
References
[1] Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.
[2] Kayed R. et al. (2004) J Bio. Chem. 279: 46363-46366.
[3] Kayed R. et al. (2003) Science. 300(5618): 486-489.
[1] Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.
[2] Kayed R. et al. (2004) J Bio. Chem. 279: 46363-46366.
[3] Kayed R. et al. (2003) Science. 300(5618): 486-489.
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