Product Name: ADAM22 (extracellular)
Product Number: AB-NN189-2
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Disintegrin and metalloproteinase domain-containing protein 22
Target Alias: MDC2; Metalloproteinase disintegrin ADAM22-3; Metalloproteinase-like disintegrin-like and cysteine-rich protein 2; ADAM 22; ADAM metallopeptidase domain 22; MGC149832
Product Type Specific: Metalloproteinase pan-specific antibody
Antibody Code: NN189-2
Antibody Target Type: Pan-specific
Protein UniProt: Q9P0K1
Protein SigNET: Q9P0K1
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Target Alias: MDC2; Metalloproteinase disintegrin ADAM22-3; Metalloproteinase-like disintegrin-like and cysteine-rich protein 2; ADAM 22; ADAM metallopeptidase domain 22; MGC149832
Product Type Specific: Metalloproteinase pan-specific antibody
Antibody Code: NN189-2
Antibody Target Type: Pan-specific
Protein UniProt: Q9P0K1
Protein SigNET: Q9P0K1
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 444-526 (extracellular disintegrin domain) of mouse ADAM22
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | ICC/Immunofluorescence | Immunoprecipitation
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects the extracellular domain of ADAM22 ~90 kDa protein in cell and tissue lysates by Western blotting. Weakly reactive in human samples.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-412 was sufficient for detection of ADAM22 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Cross Reactivity: Does not cross-react with ADAM11.
Related Product 1: ADAM22 (cytoplasmic) pan-specific antibody (Cat. No.: AB-NN189-1)
Antibody Potency: Detects the extracellular domain of ADAM22 ~90 kDa protein in cell and tissue lysates by Western blotting. Weakly reactive in human samples.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-412 was sufficient for detection of ADAM22 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Cross Reactivity: Does not cross-react with ADAM11.
Related Product 1: ADAM22 (cytoplasmic) pan-specific antibody (Cat. No.: AB-NN189-1)
Scientific Background: ADAM 22 belongs to the ADAM gene family which have been shown to bind integrin and therefore may have a part in cell to cell or cell to matrix interactions. ADAM 22 is unique in the fact that it is only observed in the nervous system and predominantly in the brain. ADAM 22 is attached by cytoskeletal scaffolds to the postsynaptic density and is a receptor for LGI1.
© Kinexus Bioinformatics Corporation 2017